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JCOM Abstract

J Clin Outcomes Manage 
2013 Jan;20(1):21-33
Pharmacotherapy for posttraumatic stress disorder
Khouzam HR

Abstract Objective: To review pharmaceutical agents studied for the treatment of posttraumatic stress disorder (PTSD). Methods: Review of the literature. Results: Evidence exists that pharmacotherapy can provide relief for the 3 core symptom clusters present in PTSD: reexperiencing, avoidance/numbing, and hyperarousal. The selective serotonin reuptake inhibitors are considered first-line pharmacotherapy for PTSD, although results are conflicting with respect to treatment of combat-related PTSD. The addition of other medications may be required to address specific aspects of the symptom spectrum and to treat co-occurring psychiatric conditions. Conclusion: There is a need for additional randomized controlled trials to confirm the effectiveness of pharmacologic treatment of PTSD.

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